“With increasing rates of tick-borne diseases and a consistent concern about the overuse of antibiotics, this early research of herbals is extremely exciting,” says Linda Giampa, executive director, Bay Area Lyme Foundation.
For the current study, the team tested the efficacy of a panel of botanical medicines and antibiotics, including azithromycin, daptomycin, doxycycline, gentamicin, methylene blue, miconazole, and rifampicin against the growing phase culture of the bacterium. Based on the analyses, they found that
Extracts of Yellow-dye root, Eastern black walnut, Japanese knotweed, Chinese skullcap, and Barbed skullcap had high activity against B. henselae
Extracts of Yellow-dye root, Eastern black walnut, and Japanese knotweed were able to eradicate all the bacterial cells within seven days
Daptomycin and methylene blue reduced the viability of the bacteria to below 40%, whereas gentamicin, rifampin, and miconazole reduced it to below 50%
Doxycycline and azithromycin were able to reduce the viability of the bacteria only to 66% and 70%, respectively
While these botanical compounds still need to undergo tests in animal models and clinical trials, this study is the first to demonstrate that Eastern black walnut, Yellow-dye root, and Japanese knotweed have high activity against Bartonella henselae .
“We are hopeful that future pre-clinical and clinical studies will continue to show that herbals have the same effect as this study and other recently-published studies,” highlighted Linda Giampa.
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