Cholesteryl Ester Transfer Protein drugs in development by Therapy Areas, Indications, Stages, MoA, RoA, Molecule Type, and Key Players, 2023
The report also covers products from therapy areas such as Metabolic Disorders, Cardiovascular, Central Nervous System, and Infectious Disease which include the indications Dyslipidemia, Heterozygous familial hypercholesterolemia (heFH), Cardiovascular, Cardiovascular Disease, Alzheimer’s Disease, and Coronavirus Disease 2019 (COVID-19). It also reviews key players involved in Cholesteryl Ester Transfer Protein targeted therapeutics development with respective active and dormant or discontinued products.
The Cholesteryl Ester Transfer Protein pipeline targets constitutes close to seven molecules. Out of which, approximately five molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Phase III, Phase II, Phase I, and Preclinical stages are 2, 1, 1, and 1 respectively. Similarly, the universities portfolio in Preclinical comprises 2 molecule.
Cholesteryl Ester Transfer Protein overview
Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein is a plasma protein that promotes the transfer of cholesteryl esters from anti-atherogenic HDLs to proatherogenic apolipoprotein B (apoB)-containing lipoproteins, including VLDLs, VLDL remnants, IDLs, and LDLs. A deficiency of CETP is associated with increased HDL levels and decreased LDL levels, a profile that is typically anti-atherogenic.
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