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What is the current valuation of AstraZeneca’s AZD-4573

AZD-4573 is a small molecule commercialized by AstraZeneca, with a leading Phase II program in Marginal Zone B-cell Lymphoma. According to Globaldata, it is involved in 3 clinical trials, of which 1 was completed, and 2 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of AZD-4573’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for AZD-4573 is expected to reach an annual total of $8 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

AZD-4573 Overview

AZD-4573 is under development for the treatment of relapsed or refractory hematological malignancies such as diffuse large B-cell lymphoma, B-cell non-Hodgkin lymphoma, T-cell non-Hodgkin lymphoma, small lymphocytic lymphoma, multiple myeloma, chronic lymphocytic leukemia (CLL), relapsed, refractory peripheral T-cell lymphoma, marginal zone b-cell lymphoma, mantle cell lymphoma, follicular lymphoma, classical Hodgkin’s lymphoma, Richter’s syndrome, AML/secondary AML, acute lymphocytic leukemia (ALL), high-risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). It is administered by intravenous route and acts by targeting cyclin-dependent kinase 9 (CDK9). It is a new molecular entity.

AstraZeneca Overview

AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The COVID-19 Vaccine AstraZeneca has been approved for conditional marketing or emergency use. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.
The company reported revenues of (US Dollars) US$44,351 million for the fiscal year ended December 2022 (FY2022), an increase of 18.5% over FY2021. The operating profit of the company was US$3,757 million in FY2022, compared to an operating profit of US$1,056 million in FY2021. The net profit of the company was US$3,288 million in FY2022, compared to a net profit of US$112 million in FY2021.

For a complete picture of AZD-4573’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

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