Treatment of Neurological Diseases is Just a Memory Away!

“Surprisingly, we found that theta oscillations in humans are more prevalent when someone is just remembering things, compared to experiencing events directly,” said lead study author Sarah Seger, a graduate student in the Department of Neuroscience.

The results of the study could have implications for treating patients with brain damage and cognitive impairments, including patients who have experienced seizures, stroke, and Parkinson’s disease, Ekstrom said.

Memory could be used to create stimulations from within the brain and drive theta oscillations, which could potentially lead to improvements in memory over time, he said.

UArizona researchers collaborated on the study with researchers from the University of Texas Southwestern Medical Center in Dallas, including neurosurgeon Dr. Brad Lega and research technician Jennifer Kriegel.

The researchers recruited 13 patients who were being monitored at the center in preparation for epilepsy surgery. As part of the monitoring, electrodes were implanted in the patients’ brains for detecting occasional seizures.

The researchers recorded the theta oscillations in the hippocampus of the brain.

Memory’s Pivotal Role

The patients participated in a virtual reality experiment, in which they were given a joystick to navigate to shops in a virtual city on a computer. When they arrived at the correct destination, the virtual reality experiment was paused.

The researchers asked the participants to imagine the location at which they started their navigation and instructed them to mentally navigate the route they just passed through. The researchers then compared theta oscillations during initial navigation to participants’ subsequent recollection of the route.

During the actual navigation process using the joystick, the oscillations were less frequent and shorter in duration compared to oscillations that occurred when participants were just imagining the route. So, the researchers conclude that memory is a strong driver of theta oscillations in humans.

One way to compensate for impaired cognitive function is by using cognitive training and rehabilitation, Ekstrom said.

“Basically, you take a patient who has memory impairments, and you try to teach them to be better at memory,” he said.

In the future, Ekstrom is planning to conduct this research in freely walking patients as opposed to patients in beds and find how freely navigating compares to memory with regard to brain oscillations.

“Being able to directly compare the oscillations that were present during the original experience, and during a later retrieval of that is a huge step forward in the field in terms of designing new experiments and understanding the neural basis of memory,” Seger said.

Reference :

1. Memory-related processing is the primary driver of human hippocampal theta oscillations
   – (https://www.sciencedirect.com/science/article/pii/S0896627323004749?via%3Dihub)

Source: Eurekalert