Tempol by DMK Pharmaceuticals for Radiodermatitis: Likelihood of Approval
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Tempol overview
Tempol is under development for the radiation-induced skin toxicity, prevention of radiation-induced oral mucositis, chemotherapy-induced toxicities, treatment of ataxia-telangiectasia (Louis-Bar syndrome), radiation induced dermatitis, recurrent glioblastoma multiforme, prostate cancer, doxorubicin induced toxicities, macular degeneration, cisplatin toxicities and paclitaxel induced toxicities. The drug candidate is administered orally and topically as a capsule and as a gel. MTS-01 (Tempol) is a piperidine nitroxide. Tempol is a membrane-permeable radical scavenger. It acts by targeting HIF-1 and HIF-2. It was under development for the treatment of alopecia and depression.
It was under development for the treatment of ARDS, cytokine storm due to COVID-19 disease, ataxia telangiectasia and peripheral neuropathy.
DMK Pharmaceuticals overview
DMK Pharmaceuticals (DMK), formerly Adamis Pharmaceuticals Corporation, is a commercial-stage neuro-biotech company that develops and commercializes products for the treatment of opioid overdose and substance use disorders. The company’s pipeline includes SYMJEPI, ZIMHI, DPI-125, DPI-221 and DPI-289. Its pipeline candidates treat anaphylaxis, opioid overdose, opioid use disorder, benign prostatic hyperplasia and parkinson’s disease. DMK develops products in the form of injections, gels and capsules for the treatment of allergies, opioid overdose and respiratory and inflammatory disease. The company supplies its products to doctors, ambulatory surgery centers, healthcare systems, hospitals and veterinarians across the US. DMK is headquartered in San Diego, California, the US.
For a complete picture of Tempol’s drug-specific PTSR and LoA scores, buy the report here.
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