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LYT-200 by Puretech Health for Metastatic Pancreatic Cancer: Likelihood of Approval

LYT-200 is under clinical development by Puretech Health and currently in Phase II for Metastatic Pancreatic Cancer. According to GlobalData, Phase II drugs for Metastatic Pancreatic Cancer have a 32% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how LYT-200’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

LYT-200 overview

LYT-200 is under development for the treatment of solid tumors such as liver cancer, metastatic pancreatic cancer, metastatic cholangiocarcinoma, autoimmune disorders, melanoma, metastatic transitional (urothelial) tract cancer, ureter cancer, bladder cancer, head and neck cancer squamous cell carcinoma, oral cavity (mouth) cancer, oropharyngeal cancer, hypopharyngeal cancer, acute myelocytic leukemia, myelodysplastic syndrome, pancreatic ductal adenocarcinoma and metastatic colorectal cancer. The drug candidate acts by targeting galectin-9.

Puretech Health overview

Puretech Health (Puretech) formerly PureTech Ventures, is a biotherapeutics company that discovers, develops, and commercializes drugs to treat lung dysfunction, immuno-oncology, lymphatic, neurological, and neuropsychological disorders. The company is investigating pipeline programs such as LYT-100 (deupirfenidone), targeting inflammation and fibrosis, lymphedema, and SARS-CoV-2 respiratory problems; LYT-200, a human monoclonal antibody for the treatment of pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC) and cholangiocarcinoma (CCA); and LYT-210, a gamma delta-1 T cell receptor against solid tumors. It is also evaluating LYT-300, oral allopregnanolone for neurological indications. Puretech works in collaboration with pharmaceutical and biotechnology companies to develop its products. Puretech is headquartered in Boston, Massachusetts, the US.

For a complete picture of LYT-200’s drug-specific PTSR and LoA scores, buy the report here.

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