How Do Multiple Species Share a Similar Mechanism of Molecular Response to Nanoparticles?

“When it comes to drugs or viruses, we have understood that any exposure or infection leaves a trace on our immune system, and that this trace will affect the way we respond to future agents. Now, we have evidence that even particulate matter primes our immunity,” says Giusy del Giudice, the first author of the scientific publication.

The detrimental effects of air pollution on respiratory functions have been long known, but only recently scientists from The Francis Crick Institute proved it to be among the driving causes of lung cancer in non-smokers. In both cases, COVID-19 and lung cancer, the impact of particulate on the immune system contributed to these effects.

“The association between particulate matter and immune activation is of utmost importance and may lead to crucial epidemiological implications,” del Giudice says.

Another important lesson learned from the COVID-19 pandemic concerns the concept of planetary health: all living organisms on the Earth are interconnected, and the effects on one specie will eventually propagate to others. In this regard, the results of this study open also new avenues to formulate integrated models that predict the effects of chemical exposures on many species at a time.

“Our results move in this direction by describing fundamental defence mechanisms common to many species throughout the tree of life”, del Giudice says.

Nanotechnology plays an important part in many fields, from biomedicine to energy and climate. Engineered nanomaterials are chemical substances or materials with particle sizes just between 1 to 100 nanometres, one third of a human hair.

Currently, thousands of consumer products contain nanomaterials, which requires testing their possible health and environmental effects. Because traditional toxicology relies on animal or in vitro tests to monitor phenotypic changes in response to exposures, it cannot keep in pace with this technological development.

“We cannot test every new nanomaterial on every possible species on Earth. We need innovative ways to reliably assess possible dangerous products as quickly as possible. Scientific evidence such as the one generated in this study can help to develop new models that do not require large amounts of animal experiments,” Grego says.

This research was carried out within the EU project NanoSolveIT that establishes computational models to test environmental health and safety of engineered nanomaterials. The study was led by FHAIVE, and it involved researchers from universities across Europe, as well as in the United States, Australia, South Africa, Japan and South Korea. Moreover, FHAIVE also develops alternatives to animal testing at a national level.

Reference :

1. An ancestral molecular response to nanomaterial particulates – (https://www.nature.com/articles/s41565-023-01393-4)

Source: Eurekalert