Treg-depleted mice were more likely to hide in darkness, moved less, and gave up on self-preservation actions more easilysuggesting that Treg-depleted mice were more anxious and depressed than control mice.
These neurobehavioral changes in Treg-depleted mice were reversed after restoration of Foxp3-expressing cells, and Treg-restored mice were more similar to controls than Treg-depleted mice were. Additionally, mice bred to model Alzheimer’s disease showed cognitive impairments when their Tregs were depleted.
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The authors posit that Treg depletion causes proliferation of peripheral immune cells, some of which can cross the blood-brain barrier into the brain and cause inflammatory responses in the hippocampal formation.
Reference :
- Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain – (https://academic.oup.com/pnasnexus/article/2/8/pgad251/7244775)
Source: Eurekalert
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#Immune #Cells #Linked #Anxiety #Depression #Alzheimers #Disease
