“Breast cancer survivors have higher rates of various age-related diseases, such as cardiovascular disease, and experience faster physical and cognitive decline than women without a history of breast cancer. In this study, we wanted to explore the biology behind this and examine whether certain cancer therapies had a greater long-term impact on survivors,” said Jacob Kresovich, Ph.D., MPH, assistant member of the Cancer Epidemiology Department at Moffitt.
The study team analyzed data from women enrolled in the Sister Study, a nationwide effort led by the National Institutes of Environmental Health Sciences, part of the NIH, to identify environmental and biological factors that contribute to breast cancer risk and survival. Over 50,000 women ages 34 to 74 who had a sister diagnosed with breast cancer, but had not been diagnosed themselves, were enrolled in the study between 2003 and 2009. Participants are contacted annually to provide health updates.
Biological Aging in Breast Cancer Patients
At the time of enrollment, participants were asked to provide a blood sample. A sample of those who provided blood were asked to do so again five to 10 years later. The researchers studied a subset of the women that provided both blood samples. Importantly, among the 417 patients included in the study, 190 were selected because they were diagnosed and treated for breast cancer between their first and second blood draws. Each blood sample was analyzed using three epigenetic metrics of biological aging: PhenoAgeAccel, GrimAgeAccel and DunedinPACE. These metrics use DNA methylation, a naturally occurring modification to DNA that changes across the lifespan, to measure how fast a person is aging at the molecular level.
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Only small differences in aging were reported based on race and the types of tumors the women developed. There were, however, important differences when it came to treatment.
“We looked at three types of treatments used for breast cancer: endocrine therapy, chemotherapy and radiation therapy. “We hope that these findings will contribute to the conversation of how to best treat and care for breast cancer survivors.”
Reference :
- Changes in methylation-based aging in women who do and do not develop breast cancer – (https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djad117/7226225)
Source: Eurekalert
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