Alpine Immune Sciences Inc Files Patent for Variant CD80-Fc Fusion Protein
According to GlobalData’s company profile on Alpine Immune Sciences, Personalized cancer vaccines was a key innovation area identified from patents. Alpine Immune Sciences‘s grant share as of January 2024 was 19%. Grant share is based on the ratio of number of grants to total number of patents.
Variant cd80-fc fusion protein for immunotherapy
A recently filed patent (Publication Number: US20240002466A1) discloses a CD80-Fc fusion immunomodulatory protein that includes a variant CD80 polypeptide and an Fc domain. The variant CD80 polypeptide contains specific amino acid substitutions, such as A71G or A71D, in the amino acid sequence of the IgV domain. This fusion protein exhibits increased binding affinity to the ectodomain of human PD-L1 compared to unmodified CD80, potentially enhancing its immunomodulatory properties.
Furthermore, the patent describes the production of the CD80-Fc fusion protein using nucleic acid molecules encoding the protein and vectors for expression in host cells. The protein can be used in various forms, including homodimers, conjugates linked to targeting moieties for specific cell binding, and pharmaceutical compositions for modulating immune responses in subjects. The Fc region of the fusion protein can be a variant with reduced effector function, and the protein may exhibit PD-L1-dependent CD28 costimulation. Overall, the patent covers a range of applications and methods related to this novel CD80-Fc fusion immunomodulatory protein, highlighting its potential in the field of immunotherapy.
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