Participants of the population-based Gutenberg Health Cohort Study where the median follow-up 11.4 years with incident MI revealed elevated C-reactive protein (CRP) at baseline and worse LVEF after MI in case of a history of noise exposure and subsequent development of noise annoyance. Left ventricular ejection fraction (LVEF) is the central measure of left ventricular systolic function. An ejection fraction below 40 percent means the heart is not pumping enough blood and may be failing. A low ejection fraction number can be an indicator of heart failure.
The lead and senior authors, Michael Molitor and Philip Wenzel commented: “We learned from our studies that aircraft noise exposure before MI substantially amplifies subsequent cardiovascular inflammation and aggravates ischemic heart failure, facilitated by pro-inflammatory vascular conditioning. Our translational results show that humans that had noise exposure in the past will have a worse outcome if they have an acute MI later in life.”
Transportation Noise may be a Risk Factor for Heart Disease
This is the first time that a translational study has been performed to investigate the effects of aircraft noise on acute myocardial infarction. In experimental animals and humans, aircraft noise markedly exaggerated the consequences of ischemia (left ventricular function, inflammation, and oxidative stress) in response to an acute myocardial infarction. There is no doubt anymore that transportation noise must be considered an important cardiovascular risk factor, comparable to hypercholesterolemia, hypertension, smoking, and diabetes mellitus.
The results of the study suggest, that measures to reduce environmental noise exposure will be helpful in improving the clinical outcome of subjects with MI.
- Aircraft noise exposure induces pro-inflammatory vascular conditioning and amplifies vascular dysfunction and impairment of cardiac function after myocardial infarction – (https:pubmed.ncbi.nlm.nih.gov/36702626/)
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