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Woman of the Week: Trevi Therapeutics’ Jennifer Good

Welcome to the Woman of the Week podcast, a weekly discussion that illuminates the unique stories of women leaders who are catalyzing change throughout the life sciences industry. You can check out all our podcast episodes here.

The entrepreneurial route is not for everybody, but when opportunity knocked, Jennifer Good answered the call. Ten years later, the CEO and president of Trevi Therapeutics said starting the company was her “wow” career moment.

In the early stages, she and co-founder Dr. Thomas Sciascia didn’t put together a business plan. They didn’t have financing lined up. There wasn’t a “whole lot of forethought” at all.

“We both decided how much of our own money we were willing to invest to try to make this happen, and we did that,” she said. “Looking back 10 years later, I’m so glad, but at the time it wasn’t so clear. It was a scary time. I was literally sitting at my kitchen table, paying the bills, and remember thinking, ‘Whew, this could be a huge mistake.’ Looking back now, I feel so proud of myself that I was willing to do that and build out what we have here.”

Today, Trevi’s lead (and only) molecule is Haduvio, an oral version of nalbuphine ER, which Good was able to purchase from Penwest Pharmaceuticals, where both she and Sciascia held C-suite roles before the biopharma was acquired.

Good recognized Haduvio’s potential, noting the molecule was “unfinished business.” After negotiating the purchase, she recalled calling Sciascia to tell him, “We’re the proud, proud owners of lots of data and now we need to figure out what to do with it.”

Over the course of the next decade, the company began a number of clinical trials for Haduvio for chronic cough conditions including interstitial lung disease, refractory chronic cough and idiopathic pulmonary fibrosis (IPF).

“We took a strategic decision that our primary focus as drug developers was going to be on the whole chronic cough space. There’s a big unmet need there,” she said. “Our drug is broadly in the opioid class, but it’s a mixed agonist antagonist. We wanted to get away from all the addiction and abuse problems in the opioid space.”

Good said the company had “an amazing 2022,” with positive readouts for two of its lead programs.

“The data in our IPF cough program was probably the best data I’ve seen in my career,” she said. “Off that, we were able to raise about $120 million. We head into 2023 with a really ambitious clinical plan around advancing IPF cough, also refractory chronic cough, and finishing a couple of other important safety studies. This is the fun part of what we do.”

In this week’s WoW program, Good shares lessons learned as an entrepreneur, the benefits of having a mission-driven culture to solve big challenges and why she is passionate about sending the elevator back down for the next generation of leaders.

 

Welcome to WoW, the Woman of the Week podcast by PharmaVoice powered by Industry Dive.

In this episode, Taren Grom, editor-in-chief emeritus at PharmaVoice, meets with Jennifer Good, president and CEO, Trevi Therapeutics.

Taren: Jennifer, welcome to the WoW podcast program.

Jennifer: Thank you for having me. I’m excited to be here.

Taren: We’re excited to have you. I love talking to entrepreneurs. You co-founded Trevi more than a decade ago. What led you to embark on this entrepreneurial journey?

Jennifer: Well, I was previously running a company called Penwest Pharmaceuticals, which was acquired by our partner. And there was an asset inside of Penwest that has sort of unfinished business for the chief medical officer and myself. My co-founder is a neurologist named Dr. Tom Sciascia, and we had worked together for a number of years. There was a drug inside of it which was not the focus of the acquisition; and Tom and I had had particular interest in it for a lot of reasons, which we’ll probably talk about is the basis of Trevi. And so when that acquisition closed, Tom and I sort of said let’s go see if we can try to get our hands on that drug. I wouldn’t say there was a lot of forethought or planning, but went down and I was able to negotiate out that asset. I joked to Tom, I called him, “We’re the proud, proud owners of lots of data and need to figure out what to do with it.” But really it was an opportunistic thing and we sort of went and got it and then thought about, “OK, where do we go from here?”

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