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Woman of the Week: Novartis’ Christy Siegel

Welcome to the Woman of the Week podcast, a weekly discussion that illuminates the unique stories of women leaders who are catalyzing change throughout the life sciences industry. This is the last installment in the podcast series but we hope to continue telling the stories of women leaders elsewhere across our site. You can check out all our past episodes here.

When Novartis entered the American Society of Clinical Oncology’s (ASCO) conference this year, the company was packing big news.

A phase 3 study testing its oncology drug Kisqali in combination with endocrine therapy showed that it reduced the risk of recurrence by 25% for early stage patients with HR+/HR- breast cancer. Already a blockbuster CDK4/6 inhibitor for advanced stage breast cancer, the results could open the door to Kisqali being used on two to three times more patients if the FDA approves it as an earlier-line therapy. 

It’s these kinds of results — from what the company called a “landmark trial” — that have kept Christy Siegel at Novartis for nearly two decades.

“Novartis invests a tremendous amount of money and resources into drug development. And not just any drug development … (but) truly transformative (products) for patients,” Siegel said. “There’s twice as many patients living with HR+ to negative early breast cancer than there are with metastatic breast cancer, so the opportunity to help those patients be cancer free for as long as possible, to live for longer, is exciting.”

Now the oncology portfolio general manager for breast and women’s cancers at Novartis, Siegel has spent 18 years working her way up the ladder at the company, mostly in specialty medicines. About a year and a half ago, Siegel, a scientist by training, moved into oncology, which she called the “hardest” area yet.

“The unfortunate reality (is) that cancer is smart and it changes,” she said. “Even when you have a patient who’s getting the best cancer care with today’s medicines, they will likely progress at some point. And so they need options.”

Personally, Siegel said Novartis’ recent trial win with Kisqali was like coming “full circle.” When asked about a “wow” moment in her career, Siegel recalled a town hall meeting at Novartis when she stood up in front of “the entire organization” and told the story of her children’s journey with epilepsy and their near-death experiences.

“For me to tell my story openly and embrace my full self and appreciate that, that experience makes me relatable both to people that I work with, to the teams I’m going to be leading and to the patients that I’m serving. So there was a power in that moment,” she said. “Then I come full circle to when we did a celebration internally for the (Kisqali) trial readout … to make an impact of that magnitude for people, to bend the curve of life, despite all my own personal emotional baggage … it was incredibly rewarding.”

In today’s episode of the Woman of Week podcast, Siegel discusses the potential of Kisqali, the mentors who’ve guided her career, her approach to leadership and her quest to “unleash the power of people.”

Welcome to while the Women of the Week podcast by PharmaVoice powered by Industry Dive. In this episode, Taren Grom, former editor-in-chief emeritus at PharmaVoice, met with Christy Segal, the oncology portfolio general manager, breast and women’s cancers at Novartis.

Taren:  Christy, welcome to the podcast program.

Christy: Happy to be here. Thanks for having me.

Taren: Christy, you have been with Novartis for more than 18 years. So I have to say, Wow, we know that’s highly unusual in this day and age, what has kept you with the organization all this time?

Christy: Yeah, I can’t even believe it’s 18 years, I usually do the math, I joined in 2005. So that’s how I do the 2023 minus 2005. And we get to it’s been 18 years, and counting. I. So at its core, I would say Novartis really connects with my values, I went into health care. Pretty quickly, when I graduated from college, I went into pharmacy school. And a lot of that is just based on who I realized I am and how I can help make a difference. So when I was younger, I, I knew pretty quickly that I wanted to work in fields, that are more pioneering in nature, and that I also really wanted to help people who needed hope. And that might be people who are, are marginalized. For people who are listening to this, you have no idea what I look like. So I have red curly hair, which as an adult is an awesome feature. But as a child, to be honest, was a little bit difficult. And so I know what it’s like to feel a bit isolated and a bit lonely. And so that that really fed into me this, this need to give back and desire to give people hope. And that if you’re wondering how does that relate to how I met, Virtus. That’s what got me into healthcare, I felt like in health care, there’s so much opportunity to help people who really, really need it. And Novartis invests a tremendous amount of money, and resources into drug development. And not just any drug development, not me to products, but truly transformative areas for patients in new mechanisms of action, new platforms that are untried, and there is risk associated with that. But I value that Novartis takes that risk, because without risks like that, we will not continue to progress, and helping people reimagine medicine and live the best lives that they can. So to be honest, I think the Novartis mission of improving and extending life very much resonates with me and my values. And as part of that, because it’s an organization that’s constantly innovating, it also creates a lot of opportunity for people. So I’ve never had a reason to leave, I have felt a tremendous amount of personal and professional growth, given the different types of opportunities I’ve had, and the different supports. I’ve also received from Novartis, in terms of coaching, as well as something called tecnam, high sustainable human performance. These are these are things that make you a better individual and a better leader. And very much resonate with me bringing my best self to work, so that I can achieve my personal vision, which is to bend the curve of life. And now with a focus specifically on the US. And as an American, who’s pretty much lived in the state of New Jersey for the majority of her life. I feel like I can take all of the experiences that I’ve had at Novartis and even j&j Before that, and really make differential impact on my personal mission. And Novartis is goal to improve and extend life.

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