What is the current valuation of Passage Bio’s PBGM-01
The revenue for PBGM-01 is expected to reach an annual total of $3 mn by 2039 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
PBGM-01 Overview
PBGM-01 is under development for the treatment of rare monogenic central nervous system disorder infantile GM1 gangliosidosis. It comprises the adeno-associated virus vector (AAVhu68) to deliver modified DNA encoding the b-gal enzyme. It acts by targeting GLB1 and administered through intra-cisterna magna injection.
Passage Bio Overview
Passage Bio is a genetic medicines company that develops therapies for the treatment of monogenic central nervous system disorders. The company’s pipeline products include PBGM01 injection to treat GM1 gangliosidosis, PBFT02 for the treatment of frontotemporal dementia (FTD), and PBKR03 for the treatment of infantile Krabbe disease, PBML04 for the treatment of metachromatic leukodystrophy and PBAL05 for the treatment of neurodegenerative disease. Passage Bio works in collaboration with the University of Pennsylvania and its gene therapy program (GTP) for preclinical works. The company also conducts clinical development, regulatory strategy, and commercialization activities. Its manufacturing and global clinical distribution center is located at Hopewell, New Jersey. Passage Bio is headquartered in Philadelphia, Pennsylvania, the US.
The operating loss of the company was US$138.4 million in FY2022, compared to an operating loss of US$185.7 million in FY2021. The net loss of the company was US$136.1 million in FY2022, compared to a net loss of US$185.4 million in FY2021.
For a complete picture of PBGM-01’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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