Vobramitamab duocarmazine by MacroGenics for Solid Tumor: Likelihood of Approval

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Vobramitamab duocarmazine overview

Vobramitamab duocarmazine (MGC-018) is under development for the treatment of solid tumors such as ovarian cancer, prostate cancer, metastatic castration-resistant prostate cancer (mCRPC), pancreatic cancer, hepatocellular carcinoma, renal cell carcinoma, castration-resistant prostate cancer (CRPC) and ocular melanoma. It acts by targeting cells expressing CD276 antigen (B7 Homolog 3 or B7-H3).  It is administered by intravenous route. The therapeutic candidate comprises of antibody-drug conjugate and it is being developed based on proprietary B7-H3 antibody and a duocarmycin-based linker payload drug technology. It was under developmernt for triple negative breast cancer, non-small cell lung cancer, head and neck squamous cell carcinoma and metastatic uveal melanoma.

MacroGenics overview

MacroGenics is a biopharmaceutical company which focuses on the development and delivery of novel antibody-based therapeutics for the treatment of cancer, infectious diseases and autoimmune disorders. Its product pipeline includes candidates for the treatment of solid tumors, HIV, breast and gastroesophageal cancers, type 1 diabetes, DART product candidates for the treatment of acute myeloid leukemia and myelodysplastic syndrome; and b-cell malignancies. The company’s product candidates are based on proprietary technology platforms, namely, Cancer Stem Cell Platform, Dual-Affinity Re-Targeting (or DART) and TRIDENT Platform and FC Optimization Platform. It works in collaboration with various pharmaceutical and biotechnology companies to leverage its technology platforms and protein engineering capabilities for development. MacroGenics is headquartered in Rockville, Maryland, the US.

For a complete picture of Vobramitamab duocarmazine’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.