“We want to elucidate molecular mechanisms of obesity in order to be able to offer patients tailor-made therapies in the future,” adds HI-MAG director Professor Matthias Blüher. The speaker of Collaborative Research Centre 1052 Obesity Mechanisms has been conducting research on morbid obesity at Leipzig University for years.
The present study also involves scientists from Leipzig who work in the fields of cardiology and laboratory medicine.
The researchers then asked whether a healthy diet could reduce the disease-causing molecular signatures induced by a bad diet. Their results show that a healthy diet can indeed improve the molecular health of blood vessels, albeit only partially. For instance, the blood vessels in the liver recovered nearly completely, but blood vessels in the kidneys retained the disease signature, despite a healthy diet and significant weight loss. This means that some of our blood vessels can develop a ‘memory’ of metabolic disease, which is difficult to reverse.
How to Prevent Obesity
Researching the mechanisms and treatment of obesity has been a focus of university research in Leipzig for many years. There is a diverse research landscape dedicated to the prevention and treatment of the disease.
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Obesity research in Leipzig encompasses a wide range of topics, including genetic associations, metabolic disorders, mechanisms of fat accumulation, the role of the brain in eating, and therapeutic interventions for losing and maintaining weight.
The Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) is a joint institution of Helmholtz Munich with Leipzig University’s Faculty of Medicine and Leipzig University Hospital. The institute investigates the molecular basis of morbid obesity in order to enable precise therapies for obesity and its secondary diseases by means of a clinical and translational research approach.
Source: Eurekalert
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