Uncovering the Role of IL-17 Protein in Skin Aging

“Single cell sequencing has allowed us to dive deep into the complexity of cell types and states forming the skin and how these change during lifespan. We did not only find differences in the composition of aged skin, but also changes in cell activity states. Particularly immune cells showed specific age-related profiles, which we could pinpoint by analyzing thousands of individual cells on at a time,” says Dr. Holger Heyn, head of the Single Cell Genomics laboratory at CNAG.

Immune Cells, Inflammation, and Aging

In addition to a wide variety of epithelial cells, hair follicle cells, and other components, the skin is also home to immune cells, which play a crucial role in preventing infection and protecting against different damages.

The study describes how, during aging, the presence of some of these immune cells, namely gamma delta T cells, innate lymphoid cells, and CD4+ T cells, significantly increases in the skin. These same cells also start expressing very high levels of the pro-inflammatory cytokine IL-17.

“Aging is associated with mild but persistent inflammation and, in the skin, this is characterised by a significant increase in IL-17, which causes skin deterioration,” explains Dr. Paloma Sol, first author of the paper, together with Dr. Elisabetta Mereu, who is now a researcher at the Josep Carreras Leukemia Research Institute.

Reversing the Symptoms of Aging in Skin

Previous studies had described that IL-17 is related to some autoimmune skin diseases, such as psoriasis, and there are existing treatments that block this protein. The team of researchers studied the response of various aspects to blocking IL-17 activity, including hair follicle growth, transepidermal water loss, wound healing, and genetic markers of aging. These four parameters showed an improvement after treatment, as the acquisition of these aging traits was significantly delayed.

“IL-17 protein is essential for vital body functions, such as defense against microbes and wound healing, so permanently blocking it would not be an option. What we have observed is that its temporary inhibition offers benefits that could be of interest at a therapeutic level,” says Dr. Guiomar Solanas, associate researcher at IRB Barcelona.

Future work by the researchers will focus on clarifying the aging processes that are related to inflammatory states in the skin and how these are linked to IL-17. The team will also address whether IL-17 is involved in the aging and deterioration of other tissues and organs.

This research has received funding from the European Research Council (ERC), the Government of Catalonia, the Spanish Ministry of Science and Innovation, the Lilliane Bettencourt Foundation, the State Research Agency (AEI), and the European Regional Development Fund (ERDF).

Reference :

1. Targeting lymphoid-derived IL-17 signaling to delay skin aging – (https://www.nature.com/articles/s43587-023-00431-z)

Source: Eurekalert