Those are findings from the SECURE trial led by Valentin Fuster, MD, Ph.D., President of Mount Sinai Heart, Physician-in-Chief of The Mount Sinai Hospital, and General Director of CNIC. The groundbreaking results were published in
.
The results showed for the first time that the cardiovascular polypill that we helped develop led to clinically relevant reductions in recurrent cardiovascular events in patients who had suffered a myocardial infarction.
Polypills: An Essential Medicine for Heart Diseases
Adherence to treatment after an acute myocardial infarction is essential for effective secondary prevention. This cardiovascular polypill, as a strategy that combines three of the baseline treatments for these patients, has proven its value, because increased adherence means that patients are being treated for longer and, as a result, have a lower risk of cardiovascular events.
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The Essential Medicines List contains medicines that the WHO considers to be the minimum requirements for any health care system. It is updated every two years and is internationally recognized, helping to prioritize effective and affordable medicines.
As stated in the WHO report, Essential medicines are those that satisfy the priority healthcare needs of a population. They are intended to be always available in functioning health systems, in appropriate dosage forms, of assured quality, and at prices individuals and health systems can afford.
The polypill is marketed under the brand names Trinomia®, Sincronium®, and Iltria®, depending on the country. It is the only polypill designed exclusively for patients who have experienced a cardiovascular event that is commercially available in 25 countries, and the feasibility of extending its distribution to additional territories, including the United States, is under analysis.
The inclusion of this therapeutic solution in the WHO’s List of Essential Medicines confirms our aim to make a positive impact in society and is an important step in our mission to bring significant and differential value to people with cardiovascular disease().
Since the groundbreaking study was published, there has seen an increase in polypill usage across the world and we are looking forward to having this medicine available in the United States and the rest of the countries where it is not available yet.
This cardiovascular polypill could become an integral part of global strategies to prevent cardiovascular events in patients who have suffered a heart attack and who are currently already being treated with separate mono-components. This approach has the potential to reduce the risk of recurrent disease and cardiovascular death.
References:
- Wiley, Brandon, and Valentin Fuster. The concept of the polypill in the prevention of cardiovascular disease. Annals of global health vol. 80,1 (2014): 24-34.(https://annalsofglobalhealth.org/articles/10.1016/j.aogh.2013.12.008)
- Hennawi, Hussam Al et al. “Polypill Therapy in Cardiovascular Disease: A Meta-Analysis of Randomized Controlled Trials.” Current problems in cardiology vol. 48,8 (2023): 101735. https://www.sciencedirect.com/science/article/abs/pii/S0146280623001524?via%3Dihub)
Source: Eurekalert
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