The study enrolled community-dwelling individuals aged 65 years or over, and free of cardiovascular disease, independence-limiting physical disability and
. Participants were randomized 1:1 to 100 mg daily aspirin or placebo. Incident diabetes was defined as self-report of
, commencement of glucose lowering medication, and/or a fasting plasma glucose (FBP) level of 7.0 mmol/L or higher at annual follow-up visits. Patients with diabetes at the start of the study were excluded. Computer and statistical modelling assessed the effect of aspirin on incident diabetes and FPG levels respectively.
A total of 16,209 participants were included in the analysis (8,086 randomized to aspirin and 8,123 to placebo). Over a median follow-up of 4.7 years, 995 incident diabetes cases were recorded (aspirin: 459, placebo: 536). Compared with placebo, the aspirin group had a 15% reduction in incident diabetes and a slower rate of increase in FPG (difference in annual FPG change: -0.006 mmol/L).
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The authors say: “Given the increasing prevalence of type 2 diabetes among older adults, the potential for anti-inflammatory agents like aspirin to prevent type 2 diabetes or improve glucose levels needs further study.”
However, Professor Zoungas adds: “The earlier published trial findings from ASPREE in 2018 showed aspirin did not prolong healthy independent living, but was associated with a significantly increased risk of bleeding, primarily in the gastrointestinal tract. Major prescribing guidelines now recommend older adults take daily aspirin only when there is a medical reason to do so, such as after a heart attack.”
“Although these new findings are of interest, they do not change the clinical advice about aspirin use in older people at this time.”
Reference :
- European Association for the Study of Diabetes (EASD) – (https://www.easd.org/annual-meeting/easd-2023.html#section-abstracts)
Source: Eurekalert
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