The study states, that voluntary exercise training (VET) improves long-term memory in high-fat diet (HFD)-induced obese mice,
, suggesting that long-term physical activity can prevent obesity-induced cognitive decline.
Particularly, their results showed that VET upregulated Bdnf mRNA levels in the hippocampus of obese mice, but had no significant effect on BDNF protein levels in the hippocampus and blood, consistent with previous reports that the increase in BDNF expression in the hippocampus is transient and occurs only within a limited time window.
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The downregulation of TNF expression after exercise training suggests that exercise may induce a mild inflammatory stimulus in the brain, contributing to mouse memory improvement.
Reference :
- Exercise training improves long-term memory in obese mice – (https://academic.oup.com/lifemeta/advance-article/doi/10.1093/lifemeta/load043/7422812?login=false)
Source: Eurekalert
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