GSK and Arrowhead Pharmaceuticals have signed an agreement for Johnson & Johnson company Janssen Pharmaceuticals’ JNJ-3989.
GSK will obtain exclusive global rights for its further development and commercialisation.
An investigational hepatitis B virus-targeted small interfering ribonucleic acid (siRNA) therapeutic, JNJ-3989 (previously ARO-HBV) was in-licensed by Janssen in 2018 from Arrowhead.
The rights and commitments under the licence will now be assumed by GSK, including the financial commitments to Arrowhead.
GSK will pay $1bn in upfront and potential milestone-based payments to both Janssen and Arrowhead.
Janssen will bear the expenditure of continuing clinical trials of JNJ-3989, which are underway.
Access the most comprehensive Company Profiles
on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Company Profile – free
sample
Thank you!
Your download email will arrive shortly
We are confident about the
unique
quality of our Company Profiles. However, we want you to make the most
beneficial
decision for your business, so we offer a free sample that you can download by
submitting the below form
By GlobalData
Arrowhead is also entitled to receive tiered royalty payments on net product sales.
Following the licensing, GSK plans to assess JNJ-3989 along with its investigational antisense oligonucleotide bepirovirsen to treat non-cirrhotic patients with chronic hepatitis B who are receiving nucleos(t)ide analogue therapy.
The JNJ-3989 plus bepirovirsen therapy is anticipated to enter a Phase II sequential regimen trial in 2024.
The latest deal is part of GSK’s strategy to bolster its late-stage speciality therapeutics pipeline.
GSK chief scientific officer Tony Wood stated: “We are excited to build on promising results already demonstrated with bepirovirsen to investigate a novel sequential regimen with JNJ-3989.
“We believe this approach could redefine the treatment paradigm for chronic hepatitis B by helping even more patients achieve a functional cure.”
In October 2023, GSK entered a deal with Chongqing Zhifei Biological Products (Zhifei) to jointly promote the shingles vaccine, Shingrix, in China.
Source link
#GSK #Arrowhead #sign #deal #Janssens #JNJ3989
