GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Ductal Carcinoma overview
Ductal Carcinoma is early stage of breast cancer where the ductal cells of the breast tissue tend to multiply or grow uncontrollably without any evidence of metastatic. If not treated in initial stages, this could be invasive. Ductal carcinoma is represented in 4 different stages, pre invasive, non-invasive, ductal intraepithelial neoplasia, intra ductal cancer. In invasive form spread of cancer cells into surrounding tissues is observed. Cause is unknown but mutations in BRCA1 and BRCA2 are believed to be one such cause. Other risk factors are family history, age, HRT, oral contraceptives, alcohol. Mammography is the radiographic method to diagnose ductal carcinoma where screening of breasts is done and tissue biopsy. In most cases it is asymptomatic but, in a few cases, the patients are presented with lump or swelling, pain, and a rash on the nipple. Surgery is the primary option of treatment. Either ductal cells that are cancerous are removed or the whole breast if complications of metastatic or in early stages endocrine therapy.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.
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