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Does Propranolol Cause Weight Gain? — Talkspace

Why Does Propranolol Cause Weight Gain?

We know that when we look at Propranolol side effects, weight gain is possible. The exact reason why isn’t fully understood. The drug’s ability to reduce metabolic rate might play a role. Additionally, many people report feeling hungrier than usual when they take Propranolol, which could clearly contribute to weight gain. Other possible reasons for Propranolol weight gain might include:

Social eating

If Propranolol is used for treating symptoms of anxiety in social situations, it’s reasonable that you might encounter more social eating opportunities as you start to feel better and are trying to be more social.

Reduced tolerance of exercise

According to research, beta-blockers like Propranolol can make working out more challenging, leading to weight gain. 

Psychiatry and Prescriptions Online

Receive an evaluation and prescription for mental health medication (if needed) from a psychiatry-trained medical provider.

Appetite increase

Another theory suggests that Propranolol might affect appetite hormones such as leptin and ghrelin, leading to increased hunger and food cravings. 

Brown adipose tissue (BAT) thermogenesis disruption 

Brown adipose tissue (BAT) thermogenesis disruption could be another reason Propranolol may lead to unwanted pounds, according to some research. BAT helps burn fat for energy production; however, Propranolol might interfere with this process, leading to fat accumulation instead of burning it off for fuel. 

Depression and fatigue 

Research has suggested a link between Propranolol and depression. This, especially when coupled with another side effect, fatigue, can cause some people to be less active and gain weight over time.

Hormonal modulation 

Studies show that Propranolol can alter testosterone levels. It’s also believed that using Propranolol might affect hormones like cortisol and adrenaline, which regulate energy levels. The changes in hormone levels may contribute to less energy and changes in body composition, ultimately leading to weight gain. 

Slower metabolism

Some research suggests that Propranolol might be linked to a reduced resting metabolic rate, which can lead to weight gain. Ironically, this seems to be a bigger risk for people who are more physically fit. 

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