Catenin Beta 1 drugs in development by Therapy Areas, Indications, Stages, MoA, RoA, Molecule Type, and Key Players, 2023
The report also covers products from therapy areas such as Oncology, Respiratory, Dermatology, and Non Malignant Disorders which include the indications Colorectal Cancer, Solid Tumor, Idiopathic Pulmonary Fibrosis, Scar, and Hemangiomas. It also reviews key players involved in Catenin Beta 1 targeted therapeutics development with respective active and dormant or discontinued products.
The Catenin Beta 1 pipeline targets constitutes close to 23 molecules. Out of which, approximately 17 molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Phase II, Phase I, Preclinical, and Discovery stages are 3, 1, 5, and 8 respectively. Similarly, the universities portfolio in Phase I, Preclinical, and Discovery comprises 1, 2, and 3 molecule.
Catenin Beta 1 overview
Catenin beta-1 or β-catenin is a protein that is encoded by the CTNNB1 gene. In the presence of Wnt ligand, CTNNB1 acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. It is involved in the regulation of cell adhesion, CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. It also acts as a negative regulator of centrosome cohesion. It blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
For a complete picture of Catenin Beta 1’s drug pipeline, buy the report here.
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