ACP-017 by Ascendis Pharma for Hepatocellular Carcinoma: Likelihood of Approval

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

ACP-017 overview

Small molecule is under development for the treatment of solid tumors including head and neck squamous-cell carcinoma (HNSCC), other HPV-associated cancers, melanoma, cutaneous squamous cell carcinoma (cSCC), colon cancer, merkel cell carcinoma, anal cancer, vulvar cancer, penile cancer, vaginal cancer, cervical cancer, esophageal cancer, triple-negative breast cancer, hepatocellular carcinoma, non-small cell lung cancer, oropharyngeal cancer, laryngeal cancer, hypopharyngeal cancer and oral cavity cancer. The drug candidate is a long acting prodrug of resiquimod administered through intratumoral route. It acts by targeting toll-like receptor (TLR) 7 and 8. It is developed based on the TransCon technology platform.

Ascendis Pharma overview

Ascendis Pharma is a biopharmaceutical company that focuses on developing drugs for endocrinology and oncology indications. It is investigating TransCon hGH, a long-acting human growth hormone prodrug targeting GHD (growth hormone deficiency); TransCon PTH drug to treat hypoparathyroidism by restoring physiologic levels of PTH (parathyroid hormone); and TransCon CNP, a CNP (C-type natriuretic peptide) drug against achondroplasia (ACH). It is also evaluating TransCon TLR (toll-like receptor) 7/8 agonist, and TransCon IL-2 ß/?, an interleukin-2 variant that activates the IL-2 receptor beta/gamma (IL-2Rß/?) for the treatment of cancer. Ascendis Pharma utilizes its proprietary TransCon technology platform to develop its drugs. The company operates in the US, Germany and Denmark. Ascendis Pharma is headquartered in Hellerup, Denmark.

For a complete picture of ACP-017’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.