released by the astrocytes, triggers the cancer cells to migrate. Dkk-1 is known to play a role in in Wnt signaling, a key signaling pathway linked to cancer progression.
“Crosstalk between brain niche cells and cancer cells allows invading cancer cells to permeate the blood-brain barrier. Reducing Dkk-1 levels near invading tumor cells might disrupt this crosstalk and prevent
,” said corresponding author Christopher R. Oliver, Ph.D., a post-doctoral fellow in the Merajver Lab.
Additional authors: Trisha M. Westerhof, Benjamin A. Yang, Nathan M. Merill, Joel A. Yates, Megan Altemus, Liam Russell, Anna J. Miller, Liwei Bao, Zhifen Wu, Peter J. Ulintz, Carlos A. Aguilar, Aki Morikawa, Maria G. Castro.
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Funding for this work is from National Institutes of Health grants UL1TR002240, T32CA009676, 1R21CA245597-01, P30CA046592, 5T32CA009676-23, CA196018, AI116482; METAvivor Foundation, and the Breast Cancer Research Foundation.
This work was supported by these Rogel Cancer Center Shared Resources: Cancer Data Science, Cell and Tissue Imaging, Flow Cytometry, Immune Monitoring.
Source: Eurekalert
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