When compared to those without hypnotic drug prescriptions, however, the researchers found a greater risk of death or exacerbations.
“While frequently used to treat insomnia, NBZRAs are associated with respiratory depression and even death in patients with COPD,” said lead author Jason Castaneda, MD, internal medicine resident, University of Washington, Seattle. “While multiple observational studies have shown this to be the case, these studies have lacked an active comparatoranother class of drugs to compare with NBZRAs. This can be a confounding factor given that insomnia itself is associated with these risks for COPD patients.”
To tease out the role of NBZRAs, the researchers designed a study that used thousands of medical records from the Veterans Health Administration to compare the risk of death or inpatient exacerbations for COPD patients who were given new prescriptions for NBZRAs with patients given other drugs that were hypnotics but were not NBZRAs. Among the other hypnotics were melatonin, ramelteon (Rozerem), trazodone (Desyrel, Oleptro) and doxepin (Silenor, SINEquan).
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They matched patients receiving NBZRAs and other hypnotics on 40 variables, such as demographics, medical and sleep disorders, and COPD severity. They also matched patients taking NBZRAs with those taking no hypnotic drugs. Dr. Castaneda and colleagues used a Cox statistical model to compare all-cause death or inpatient COPD exacerbation within one year.
The scientists identified 1,276 COPD patients who received new NBZRA prescriptions in the Veterans Health Administration records, and 3,372 who received new prescriptions for other hypnotics. When the NBZRA patients were matched with the same number of patients prescribed other hypnotics, the researchers found no difference in mortality or inpatient exacerbation risk.
Commenting on the meaning of the study’s findings, Dr. Castaneda stated, “The greater risk of hypnotic drugs may reflect residual, unmeasured confounding related to insomnia. It may also represent true adverse events from hypnotics that cut across hypnotic classes.”
The study was done at the VA Puget Sound Health Care System and supported by Health Services Research & Development. A number of the researchers, including senior author Lucas Donovan, MD, have dual appointments with the VA health care system and the University of Washington.
Reference :
- Risks of Non-benzodiazepine Benzodiazepine Receptor Agonists Among Patients With Chronic Obstructive Pulmonary Disease – (https://www.abstractsonline.com/pp8/#!/10703/presentation/10449)
Source: Eurekalert
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