Does Zoloft Cause Weight Gain? — Talkspace

Zoloft, also known as sertraline, is an antidepressant medication used to treat depression, anxiety, and other mental health conditions. While this selective serotonin reuptake inhibitor (SSRI) can be an effective treatment of depression and anxiety symptoms for many people, like any drug, there are potential mental and physical Zoloft side effects that can come with antidepressant use. A common side effect is Zoloft weight gain. 

Not everyone experiences sertraline weight gain. Much of the time, research shows that body weight gain is modest or temporary. That said, it’s still important to understand the potential side effect and discuss it with your doctor before starting treatment.

Does Zoloft Cause Weight Gain?

Can you gain weight on Zoloft? Some studies have shown that around 11% of people who take antidepressants experience a weight gain of at least 5% during the first year. However, your side effects may occur at different times depending on how long it takes for Zoloft to work in your body. Some research also suggests that other types of antidepressants might have a higher risk than Zoloft. 

“Zoloft can potentially cause weight gain, but it’s not a necessary side effect for everyone. It’s best to get clarity from your psychiatrist about which antidepressant is the best fit for you. You can get on another medication if you find yourself gaining weight.”

– Talkspace therapist Bisma Anwar, LMHC

What other SSRIs cause weight gain?

Body weight gain can be a side effect of antidepressant use beyond just Zoloft. Other selective serotonin reuptake inhibitors (SSRIs) that might cause weight gain include: 

• Prozac
• Paxil
• Celexa
• Lexapro 

Weight gain appears to be more likely when taking higher doses or for people taking the antidepressant drug for extended periods.  

Why Does Zoloft Cause Weight Gain?

The exact reason why you might gain weight on Zoloft isn’t fully understood, but several theories exist. 

Increased serotonin levels

One theory suggests that increased serotonin levels in the brain caused by SSRI drugs can affect metabolism and hunger signals in the body. This might lead to changes in appetite and eating habits as well as cravings for unhealthy foods, resulting in weight gain over time. 

Energy levels

Another possibility for Zoloft weight gain is that certain types of depression medications interfere with energy balance. For some people, antidepressant treatment may cause them to become less active and burn fewer calories than they usually would. 

Hormones and metabolism

Some research suggests that long-term use of SSRI drugs may alter appetite-regulating hormones like leptin and ghrelin. More research is needed, though, as it’s unclear if this results in weight gain.  

Sedative effect

Finally, another factor that could contribute to potential weight gain from taking Zoloft might be its sedative effect. Zoloft can make you feel drowsy or sleepy during the day. It’s plausible that this could reduce your activity level and increase your chance of gaining weight due to a lack of physical exercise.

Talk to Your Doctor About Zoloft Side Effects

It’s critical for anyone considering starting an antidepressant like Zoloft to understand the risks associated with its use. 

If you’re worried about Zoloft and weight gain or other side effects, share your concerns with your doctor.

Online psychiatry from Talkspace can provide professional guidance as you navigate the potential side effects of a prescribed medication. If you’re concerned with weight gain on Zoloft, explore your treatment options with a psychiatrist. Take control of your health today by seeking the right psychiatrist-prescribed medication for you.