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From Aggressive Tumors to Healthy Muscle Cells With Differentiation Therapy

that have not yet comprehensively matured into a specific cell type, has shown promising outcomes for the fatal pediatric malignancy.

This therapy forces such cells to develop further and differentiate into certain mature cell types.

NF-Y’s Potential to Transform Cancer Cells

Vakoc and his colleagues developed a novel genetic screening approach. The researchers used genome-editing techniques to track the genes that when damaged, compelled RMS cells to become muscle cells.

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Then a protein known as NF-Y entered the picture. The scientists discovered an astonishing mutation after damaging NF-Y. The newly identified link between NF-Y and RMS may put in motion the chain reaction required to deliver differentiation treatment to patients. The technology may potentially apply to other types of cancer. If this is the case, scientists may one day discover ways to convert other tumors into healthy cells.

“This technology can allow you to take any cancer and go hunting for how to cause it to differentiate,” Vakoc explains. “This might be a key step toward making differentiation therapy more accessible.”

Reference :

  1. Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma – (https:www.pnas.org/doi/10.1073/pnas.2303859120)

Source: Medindia

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